Essential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. Author Ayalew Tefferi, MD, of the Mayo Clinic, joins JAMA Associate Editor David Simel, MD, MHS, to discuss diagnosis and treatment of this condition. Related Content: Essential Thrombo…

In this episode, Shaji K. Kumar, MD, reviews key data on bispecific antibodies used to treat patients with relapsed/refractory multiple myeloma recently presented at the 2024 annual American Society of Hematology meeting, including: Early results with teclistamab combined with anti-CD38 therapy Real-world data with teclistamab including its use aft…

Guidelines from the American Thoracic Society report on the value of pulmonary rehabilitation for people with COPD, interstitial lung disease, or pulmonary hypertension. JAMA Clinical Guidelines Synopsis author Michaela R. Anderson, University of Pennsylvania, discusses these guidelines and more with JAMA Associate Editor David Simel, MD, MHS. Rela…

Interview with Esa M. Davis, MD, MPH, USPSTF member and coauthor of Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Osteoporosis to Prevent Fractures Screening for Osteoporosis to Prevent …

In this episode, listen to Virginia Kaklamani, MD, DSc; Erica L. Mayer, MD, MPH; and Laura M. Spring, MD, share their clinical insights and takeaways from a live symposium, including from key abstracts presented at the 2024 San Antonio Breast Cancer Symposium: Estrogen receptor mutations in patients With HR-positive/HER2-negative advanced breast ca…

NIH'S policies, programs, and research funding fill gaps in knowledge about women’s health. Janine Austin Clayton, MD, of the NIH joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss key programs, policies, and scientific advances of the NIH that have informed and improved women’s health. Related Content: Recent Developments…

JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA 2024 Clinical Reviews podcasts. Related Content: Dialysis for Chronic Kidney Failure (podcast) Diagnosis and Treatment of Community-Acquired Pneumonia (CAP) (podcast) Obesity Medications (podcast) Dialysis for Chronic Kidney …

Chronic kidney disease develops among 30% to 40% of people with type 1 or type 2 diabetes during their lifetime. Author Ian H. de Boer, MD, MS, of the University of Washington Division of Nephrology, discusses the evaluation and treatment of chronic kidney disease in patients with type 1 and type 2 diabetes with JAMA Senior Editor Karen Lasser, MD,…

The number of people living with atrial fibrillation (AF) is increasing, and they have a higher rate of cardiovascular events, chronic kidney disease, and dementia compared with people without AF. Emelia J. Benjamin, MD, ScM, an epidemiologist and cardiologist, discusses current diagnosis and treatment of AF with JAMA Deputy Editor Mary McGrae McDe…

Allogeneic stem cell transplantation is a potentially life-saving therapy for some patients with hematologic and bone marrow cancers and certain nonmalignant conditions such as sickle cell disease. Hermioni L. Amonoo, MD, MPP, MPH, of Harvard Medical School and Dana-Farber Cancer Institute, joins JAMA Deputy Editor Kristin Walter, MD, MS, to discus…

JAMA Senior Editor Derek Angus, MD, MPH, and JAMA Associate Editor Christopher Seymour, MD, MSc, discuss 4 critical care trials published in JAMA and simultaneously presented at the 2024 CCR Down Under meeting in Melbourne, Australia, with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Electronic Sepsis Screening Among…

Access to obstetric care in US hospitals has been declining, while maternal mortality is on the rise. A new research letter published in JAMA quantifies losses and gains of obstetric care at rural and urban short-term acute care hospitals in the US between 2010-2022. Author Katy Kozhimannil, PhD, MPA, discusses this and more with JAMA Deputy Editor…

Ovarian aging is an important cause of infertility in women older than 35 years. Success rates of fertility treatment decline with age, most commonly due to declining ovarian function. Author Albert L. Hsu, MD, MS, of University of Cincinnati, Ohio, discusses this and more with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content: Ovarian …

Mpox is an evolving global health threat, and clinicians should be aware of characteristic signs and symptoms to ensure timely diagnosis and appropriate management. Author Jason Zucker, MD, MS, of Columbia University Irving Medical Center speaks with JAMA Deputy Editor Preeti Malani, MD, MSJ, about the transmission, diagnosis, management, and preve…

Calcific aortic stenosis affects approximately 12% of people >75 years in the US and worldwide leads to more than 100 000 deaths each year. Catherine M. Otto, MD, PhD, of the University of Washington School of Medicine, Seattle, discusses the symptoms, diagnosis, and treatment of aortic stenosis with JAMA Deputy Editor Kristin L. Walter, MD, MS. Re…

CAR T cells are genetically engineered to express a receptor that recognizes and kills tumor cells. CAR T-cell products are now FDA approved for 6 hematologic malignancies. Author Jennifer N. Brudno, MD, National Cancer Institute, joins JAMA Deputy Editor Mary McGrae McDermott, MD, to discuss "CAR T Cells and T-Cell Therapies for Cancer: A Translat…

Peptic ulcer disease affects approximately 1% of the population in the US, and H pylori is a common cause of peptic ulcer disease. Author Nimish Vakil, MD, a gastroenterologist from the University of Wisconsin, Madison, discusses current evidence regarding diagnosis and treatment of peptic ulcer disease with JAMA Deputy Editor Mary McGrae McDermott…

In this episode, Caitlin Costello, MD, discusses important topics related to relapsed/refractory (R/R) multiple myeloma (MM), including: 3 bispecific antibodies approved for the treatment of R/R MM that target BCMA or GPRC5D The role of bispecific antibodies in R/R MM Safety considerations for patients while receiving a bispecific antibody Emerging…

High prescription costs are a major barrier to the optimal treatment of many health conditions. Prescribers need tools to help patients find the lowest drug costs. Author Hussain S. Lalani, MD, MPH, MSc, of Brigham and Women's Hospital and Harvard Medical School joins JAMA Senior Editor Anne R. Cappola, MD, ScM, to discuss "Strategies to Help Patie…

In this episode, Thor R. Halfdanarson, MD, and Jonathan Strosberg, MD, discuss important topics related to gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including: The diagnosis and typical presenting symptoms of GEP-NETs Findings from recent key phase III studies including NETTER-2 and CABINET Recommendations for treatment sequencing No…

Even though highly effective medications are currently available to prevent HIV, there are about 1.3 million new infections worldwide each year. Monica Gandhi, MD, MPH, of the University of California San Francisco joins JAMA Senior Editor Karen E. Lasser, MD, MPH, to discuss preexposure prophylaxis (PrEP) for HIV. Related Content: Preexposure Prop…

In July 2023, the US Food and Drug Administration (FDA) approved Opill, a daily progestin-only oral contraceptive for over-the-counter sale to people of all ages. Daniel Grossman, MD, discusses this and more with JAMA Associate Editor Melissa A. Simon, MD, MPH. Related Content: Over-the-Counter Oral Contraceptives Over-the-Counter Oral Contraceptiv…

Selection of hemodialysis or peritoneal dialysis and timing of dialysis initiation are influenced by patient symptoms, laboratory trajectories, patient preferences, and therapy cost and availability; shared decision-making is key. Jennifer E. Flythe, MD, MPH, from the University of North Carolina, discusses dialysis for chronic kidney failure with …

In this episode, listen to Ana Oaknin, MD, PhD and Alexandra Leary, MD, PhD, share their clinical insights and takeaways on key updates and new data presented for ovarian, endometrial, and cervical cancer at the ESMO 2024 annual congress including: Phase III PRIMA/ENGOT-OV26/GOG-3012 Final OS Results: Niraparib as First-Line Maintenance in Advanced…

In this episode, listen to Matthew S. Davids, MD, MMSc​, and Lindsey Roeker, MD, discuss BTK inhibitor resistance and how it shapes treatment choices for patients with CLL, including: Contemporary treatment paradigms for patients with CLL Safety and efficacy of current regimens Molecular testing, including when and how to test for BTK inhibitor res…

Chronic spontaneous urticaria affects approximately 1% of the general population worldwide, impairs patients’ quality of life, and is associated with multiple comorbidities. Pavel Kolkhir, MD, discusses the current evidence on the epidemiology, pathophysiology, diagnosis, and treatment of chronic spontaneous urticaria with JAMA Senior Editor Karen …

Community-acquired pneumonia is associated with approximately 740 000 hospitalizations and 41 000 deaths in the US annually. JAMA Review authors Scott A. Flanders, MD, and Valerie M. Vaughn, MD, MSc, discuss diagnosis and treatment of community-acquired pneumonia with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content: Community-Acquired…

Infestations by ectoparasites such as scabies, bedbugs, and body lice are common. Diagnosis requires history, including social drivers of health such as living environment, and physical examination. Author Aileen Y. Chang, MD, of UCSF, joins JAMA Senior Editor Karen Lasser, MD, to discuss Scabies, Bedbug, and Body Lice Infestations: A Narrative Rev…